HGH Peptide Therapy

“The Why.”

A person’s natural HGH production significantly declines with age, beginning in their 20’s and beyond. This is a well-established physiological process.

The decline pattern:

• HGH production peaks during childhood and adolescence (when growth is most active).
• It begins declining in your 20s and continues dropping throughout life.
• By age 60, most people produce only about 15-20% of the HGH they made in their youth.
• The decline is roughly 14-15% per decade after age 30.

Why this happens:

• The pituitary gland becomes less responsive to growth hormone-releasing hormone (GHRH).
• Somatostatin (which inhibits HGH release) increases with age.
• Sleep quality often decreases with age, reducing the deep sleep phases when most HGH is released.
• Overall metabolic changes affect hormone production.

Effects of Declining HGH:

• Decreased muscle mass and strength
• Increased body fat, especially abdominal fat
• Reduced bone density
• Slower wound healing and recovery
• Changes in skin thickness and elasticity
• Potential impacts on energy levels and mood
• Altered metabolism

This age-related decline is signaled by the decline of natural hormone production, in general, as people age beyond their 30’s.  

Why Sermorelin?

Sermorelin is a 29 amino acid analogue of human “Growth Hormone-Releasing Hormone (GHRH)”, and is the shortest synthetic peptide with full biological activity of GHRH.

Peptide Function: Peptides often act as hormones, neurotransmitters, or signaling molecules

• More easily absorbed – Peptides are more easily absorbed than Exogenous H Peptides are best delivered by SQ injection.
• Rather than providing Exogenous aka external HGH directly, Sermorelin stimulates the patient’s own pituitary gland by binding to specific receptors to increase natural production and secretion of Endogenous HGH.
• Endogenous means: “To stimulate and optimize the natural, internal production of HGH hormone, which your body produces.”

How it works:

Sermorelin is a synthetic version of growth hormone–releasing hormone (GHRH), a hormone that tells your pituitary gland to produce and release more natural HGH.  This approach stimulates your body’s own hormone production rather than replacing it entirely.

Advantages over direct HGH:

Sermorelin is considered a safer alternative to synthetic HGH therapy as it does not suppress natural hormone production and has minimal side effects.  Instead, it stimulates natural hormone production.  It is also less likely to cause the hormonal disruption that can occur with direct HGH injections, because it works with your body’s natural systems.

Administration:

Sermorelin is administered through a once a day (SQ) Subcutaneous injection before bedtime, Monday through Friday.  The timing aligns with your body’s natural growth hormone production cycle during sleep.

Benefits of Sermorelin

• Increasing energy from fat breakdown
• Increases protein synthesis – increases lean muscle
• Increasing muscle mass through sarcomere hyperplasia (additional division of the contractile unit of a muscle)
• Decreases body fat and increases Lipolysis (fat burning)
• Strengthens immune system – reduces risk factors for age related diseases
• Strengthening of joints and connective tissue
• Increases bone density – Increases calcium retention
• Stimulates the growth of all internal organs to more a youthful state
• Improving cognitive abilities

Cardiac Health

Based on the research, Sermorelin appears to have some potential benefits for cardiac health, though the evidence is still developing:

Potential cardiac benefits: Sermorelin affected sleep and cardiac function in studies examining its effects. More specifically, researchers have recognized that Sermorelin can reduce cardiac scarring, or fibrosis, and help preserve healthy heart. Additionally, it has excellent potential to improve overall heart health, especially after a heart attack.

Mechanism: These cardiac benefits likely stem from Sermorelin’s ability to stimulate growth hormone release. People who suffer from adult growth hormone deficiency are more likely to suffer from heart attacks, as HGH levels are not sufficient to maintain organ health. Restoring growth hormone levels, Sermorelin may help maintain cardiovascular health.

Sermorelin versus synthetic HGH therapy

Numerous studies, including AMA/JAMA referenced studies have concluded the following:

• Patients, who were treated with Sermorelin, lost adipose (fat) and increased lean muscle, significantly improving total body composition.

• Sermorelin was safer than using Exogenous growth hormone, since it did not cause insulin resistance, muscle/joint pain nor did it suppress natural production of HGH. Instead, it restored and optimized natural production of HGH.

• Conclusion: Sermorelin was well tolerated and effectively increased levels of IGF-1.

• Total and regional body composition improved in response to Sermorelin, with increased lean mass and reduced truncal and visceral fat.

Important considerations:

• Sermorelin requires a prescription and medical supervision.
• It’s currently the only FDA-approved peptide available for this purpose.

If you’re considering Sermorelin, it is highly recommended that you work with a healthcare provider, who specializes in hormone therapy.

RenewFX Health | RenewFX.com

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